Salivary glands

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Salivary glands

Other tumors

Lipoma

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 27 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Benign tumor; rare in salivary glands, but usually involves parotid gland (Laryngol Rhinol Otol 1986;65:485)
● More common than lipomatosis
● Clinical findings are nonspecific (J Oral Maxillofac Surg 2006;64:1583)

Clinical features
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● 3% of parotid tumors - #2 most common benign mesenchymal neoplasms of major salivary glands (#1 is schwannoma)
● Often incidental (Rev Stomatol Chir Maxillofac 1988;89:117)
● Ages 40+, usually men, occasionally children

Case reports
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● Infant girl with parotid angiolipoma (Laryngoscope 1988;98:818)
● 36 year old woman with 3.5 cm parotid lipomatous pleomorphic adenoma (Pathol Res Pract 1999;195:247)
● 44 year old man with slow growing, asymptomatic parotid mass (Diagn Cytopathol 2013;41:171)
● 47 year old man with spindle cell lipoma of parotid gland diagnosed by fine needle aspiration (Arch Pathol Lab Med 2001;125:820)
● 56 year old man (Br J Oral Maxillofac Surg 2010;48:203)

Treatment
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● Simple excision, usually do not recur (J Korean Med Sci 1996;11:522, Arch Otolaryngol 1976;102:230)

Micro description
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● Bland appearing adipose tissue; osteolipoma or angiolipoma variants exist

Micro images
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Spindle cell lipoma of parotid gland

Pleomorphic lipoma with classic floret-like cells

Chondroid lipoma of lip has chondroid and lipomatous features

Cytology description
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● Nonspecific findings (Eur Arch Otorhinolaryngol 2008;265:S47); spindle cell lipomas have bland appearing spindle cells in myxoid background, CD34+ mature fat cells; S100 may be negative

Cytology images
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Spindle cell lipoma: bland spindle cells with myxoid change and fat, CD34+

Differential diagnosis
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● Pleomorphic adenoma: may have extensive lipometaplasia / lipomatosis (Am J Surg Pathol 2005;29:1389)

End of Salivary glands > Other tumors > Lipoma

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