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Salivary glands

Other tumors

Melanoma


Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 28 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Unusual site; typically sheets of cells with abundant eosinophilic cytoplasm and prominent nucleoli
● Median age 66 years, range 30-84 years
● Usually represents metastatic disease from head and neck, and is common metastasis to parotid (Arch Pathol Lab Med 2000;124:1780)

Clinical features
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● Often represents metastatic disease
● Primary parotid tumors may be amelanotic
● Intraparotid sentinel lymph node often assessed for head and neck melanoma staging (Laryngoscope 2006;116:1461)
● Clinically presents with rapid increase in size
● Poor prognosis due to distant spread (Laryngoscope 2003;113:1070); rare patients have prolonged survival after surgery

Case reports
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● 40 year old woman with rapidly growing submandibular mass (Turk Patoloji Derg 2011;27:77)
● 71 year old man with jejunal melanoma metastatic to parotid (J Am Acad Dermatol 2003;49:319)
● Parotid mass (Diagn Cytopathol 2011;39:373)
● Primary melanoma of parotid (Acta Cytol 2009;53:435)
● Amelanotic melanoma primary in parotid (J Int Med Res 2008;36:1435)

Treatment
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● Surgery, radiotherapy for primary melanoma

Gross description
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● Often multiple nodules

Micro description
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● Sheets of cells with abundant eosinophilic cytoplasm and prominent nucleoli
● Often spindle cell regions, angiolymphatic invasion, desmoplasia; may metastatise in salivary gland pleomorphic adenoma

Micro images
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Various melanomas

Micro images
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Desmoplastic melanoma metastatic to submandibular gland


Left: parotid lymph node, right: parotid gland


Left: S100, right: HMB45

Positive stains
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● S100, HMB45, MART1

Differential diagnosis
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Schwannoma
● Undifferentiated carcinoma

End of Salivary glands > Other tumors > Melanoma


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