Mikulicz’s disease and syndrome
Reviewers: Fatima Aly, M.D., National Cancer Institute (see Reviewers page)
Revised: 7 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Outdated terms
● Mikulicz disease referred to an idiopathic, painless, bilateral enlargement of lacrimal and salivary glands
● Mikulicz syndrome was similar, but due to identifiable disease processes such as tuberculosis, sarcoidosis, HIV infection
● Initially polyclonal, may evolve into lymphoma (MALT lymphoma, diffuse large B cell, SLL/CLL, rarely Hodgkin’s lymphoma, peripheral T cell lymphoma)
● Solid gray-white areas and occasional cysts
● Marked lymphocytic infiltration with lymphoid follicles surrounding solid epithelial nests (epimyoepithelial islands)
● Also scattered histiocytes and dendritic cells
● Excess hyaline basement membrane material deposited between cells
● Also acinar atrophy and destruction, lymphoepithelial lesions, monocytoid B cells
● Usually no fibrosis, no involvement of large ducts
End of Salivary Glands > Inflammation > Mikulicz’s disease and syndrome
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).