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Salivary glands

Inflammation

Mikulicz’s disease and syndrome


Reviewers: Fatima Aly, M.D., National Cancer Institute (see Reviewers page)
Revised: 7 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

General
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● Outdated terms
● Mikulicz disease referred to an idiopathic, painless, bilateral enlargement of lacrimal and salivary glands
● Mikulicz syndrome was similar, but due to identifiable disease processes such as tuberculosis, sarcoidosis, HIV infection
● Initially polyclonal, may evolve into lymphoma (MALT lymphoma, diffuse large B cell, SLL/CLL, rarely Hodgkin’s lymphoma, peripheral T cell lymphoma)

Gross description
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● Solid gray-white areas and occasional cysts

Micro description
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● Marked lymphocytic infiltration with lymphoid follicles surrounding solid epithelial nests (epimyoepithelial islands)
● Also scattered histiocytes and dendritic cells
● Excess hyaline basement membrane material deposited between cells
● Also acinar atrophy and destruction, lymphoepithelial lesions, monocytoid B cells
● Usually no fibrosis, no involvement of large ducts

End of Salivary Glands > Inflammation > Mikulicz’s disease and syndrome


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