Salivary glands
Epithelial / myoepithelial tumors
Oncocytoma


Topic Completed: 1 September 2012

Revised: 21 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Oncocytoma[TI] salivary glands
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Cite this page: Handra-Luca A Oncocytoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsoncocytoma.html. Accessed April 25th, 2019.
Definition / general
  • Benign tumor composed of oncocytes
  • Also called oxyphilic adenoma
  • 1 - 2% of salivary gland neoplasms; more frequent than oncocytosis and oncocytic carcinoma
Clinical features
  • Usually parotid gland mass, also submandibular gland or minor salivary glands
  • Mean age 60 years
  • 20% associated with radiation therapy or radiation exposure
  • Rarely bilateral, multiple
  • Rarely synchronous with Warthin tumor or carcinoma ex pleomorphic adenoma
  • May occur in trisomy 7 or in BHD syndrome
Radiology description
Case reports
Treatment
  • Local excision
  • Excellent prognosis but may have late recurrence
Gross description
  • Well circumscribed with fibrous capsule, solid, tan-red-brown, lobulated, often small, may have cystic spaces
Microscopic (histologic) description
  • Eosinophilic or clear cell (glycogen) with sheets, trabeculae, acini or follicular patterns of monotonous large polygonal cells with well defined cell borders, deeply eosinophilic, granular cytoplasm, small round nuclei
  • Vascular stroma, may have clear cell change, background of oncocytic nodular hyperplasia, psammoma bodies, tyrosine rich crystals
  • No mitotic figures, no elastosis
Microscopic (histologic) images

Images hosted on other servers:

Various images

Red-brown tumor with
central scar, oncocytes
packed with mitochondria,
oncocytic metaplasia of ducts

Cytology images

Images hosted on other servers:

Various images

Positive stains
Electron microscopy description
  • Packed with mitochondria with partitions
Differential diagnosis
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