Salivary glands
Epithelial / myoepithelial tumors
Oncocytoma

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 16 March 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Oncocytoma[TI] salivary glands

Cite this page: Handra-Luca, A. Oncocytoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsoncocytoma.html. Accessed October 17th, 2018.
Definition / general
  • Benign tumor composed of oncocytes
  • Also called oxyphilic adenoma
  • 1 - 2% of salivary gland neoplasms; more frequent than oncocytosis and oncocytic carcinoma
Clinical features
  • Usually parotid gland mass, also submandibular gland or minor salivary glands
  • Mean age 60 years
  • 20% associated with radiation therapy or radiation exposure
  • Rarely bilateral, multiple
  • Rarely synchronous with Warthin tumor or carcinoma ex pleomorphic adenoma
  • May occur in trisomy 7 or in BHD syndrome
Radiology description
Case reports
Treatment
  • Local excision
  • Excellent prognosis but may have late recurrence
Gross description
  • Well circumscribed with fibrous capsule, solid, tan-red-brown, lobulated, often small, may have cystic spaces
Microscopic (histologic) description
  • Eosinophilic or clear cell (glycogen) with sheets, trabeculae, acini or follicular patterns of monotonous large polygonal cells with well defined cell borders, deeply eosinophilic, granular cytoplasm, small round nuclei
  • Vascular stroma, may have clear cell change, background of oncocytic nodular hyperplasia, psammoma bodies, tyrosine rich crystals
  • No mitotic figures, no elastosis
Microscopic (histologic) images

Images hosted on other servers:

Various images

Red-brown tumor with
central scar, oncocytes
packed with mitochondria,
oncocytic metaplasia of ducts

Cytology images

Images hosted on other servers:

Various images

Positive stains
Electron microscopy description
  • Packed with mitochondria with partitions
Differential diagnosis