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Salivary glands

Epithelial / myoepithelial tumors

Oncocytosis

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 27 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Either parotid cysts lined by oncocytes or well defined clusters of oncocytes (mm to cm)
● First reported by Schwartz (Cancer 1969;23:636)
● Also called multinodular oncocytoma, multifocal adenomatous oncocytic hyperplasia

Clinical features
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● Benign, multifocal / nodular or diffuse proliferation of oncocytic cells, usually in parotid gland
● May be bilateral

Case reports
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● 68 year old man with 6 cm parotid swelling (J Cytol 2012;29:80)
● 78 year old man (Laryngorhinootologie 2004;83:185)

Micro description
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● Either parotid cysts lined by oncocytes or well defined clusters of oncocytes (mm to cm)
● Oncocytes (oxyphilic cells) are large ductal epithelial cells with eosinophilic granular cytoplasm

Micro images
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Parotid gland specimen

Cytology description
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● Oncocytic cells

Cytology images
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Various images

Electron microscopy description
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● Numerous mitochondria

Differential diagnosis
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● Normal aging: increased oncocytes
● Oncocytoma: distinct mass
● Rhabdomyoma: may resemble at intraoperative frozen section; positive for skeletal muscle markers; different morphology on permanent section (Arch Pathol Lab Med 1983;107:638)
● Sialadenosis: may resemble diffuse oncocytosis (Laryngol Rhinol Otol (Stuttg) 1982;61:691)
● Warthin’s tumor: double layer of epithelial cells resting on dense lymphoid stroma with variable germinal centers

End of Salivary glands > Epithelial / myoepithelial tumors > Oncocytosis

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