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Salivary glands

Epithelial / myoepithelial tumors

Oxyphilic carcinoma

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 27 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Malignant counterpart of oncocytoma
● Also called malignant oncocytoma, oncocytic carcinoma

Clinical features

● Very rare; usually males, tumor of parotid or submandibular gland
● High grade tumor that arises de novo or in oncocytoma (J Oral Pathol Med 1998;27:225)
● May occur after radiotherapy (J Exp Clin Cancer Res 1998;17:65)
● Disease specific 5-year survival of 54% (Oral Oncol 2010;46:773)
● May recur, have regional / distant metastases (including bone)

Case reports

● 53 year old man with oncocytic carcinoma ex pleomorphic adenoma (Head Neck Pathol 2010;4:49)
● 67 year old man with metastatic tumor to bone (South Med J 2009;102:659)

Micro description

● Adenocarcinoma type architecture, malignant appearing oncocytic cells with infiltrative growth, mucus production, perineural invasion
● Atypia, mitotic figures
● May occur in pleomorphic adenoma

Micro images

Oncocytic carcinoma ex pleomorphic carcinoma

Various images

Positive stains

● PTAH, p63 (Head Neck Pathol 2007;1:123), MA903; increased MIB1 / Ki-67 rate

Differential diagnosis

● Renal cell carcinoma: p63 negative

End of Salivary glands > Epithelial / myoepithelial tumors > Oxyphilic carcinoma

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