Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Salivary glands

Epithelial / myoepithelial tumors

Oxyphilic carcinoma


Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 27 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Malignant counterpart of oncocytoma
● Also called malignant oncocytoma, oncocytic carcinoma

Clinical features
=========================================================================

● Very rare; usually males, tumor of parotid or submandibular gland
● High grade tumor that arises de novo or in oncocytoma (J Oral Pathol Med 1998;27:225)
● May occur after radiotherapy (J Exp Clin Cancer Res 1998;17:65)
● Disease specific 5-year survival of 54% (Oral Oncol 2010;46:773)
● May recur, have regional / distant metastases (including bone)

Case reports
=========================================================================

● 53 year old man with oncocytic carcinoma ex pleomorphic adenoma (Head Neck Pathol 2010;4:49)
● 67 year old man with metastatic tumor to bone (South Med J 2009;102:659)

Micro description
=========================================================================

● Adenocarcinoma type architecture, malignant appearing oncocytic cells with infiltrative growth, mucus production, perineural invasion
● Atypia, mitotic figures
● May occur in pleomorphic adenoma

Micro images
=========================================================================



Oncocytic carcinoma ex pleomorphic carcinoma


Various images

Positive stains
=========================================================================

● PTAH, p63 (Head Neck Pathol 2007;1:123), MA903; increased MIB1 / Ki-67 rate

Differential diagnosis
=========================================================================

● Renal cell carcinoma: p63 negative

End of Salivary glands > Epithelial / myoepithelial tumors > Oxyphilic carcinoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).