Salivary glands
Developmental disorders
Polycystic disease

Author: F. Zahra Aly, M.D., Ph.D. (see Authors page)

Revised: 12 March 2018, last major update August 2011

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Polycystic disease salivary glands

Cite this page: Aly, F.Z. Polycystic disease. website. Accessed March 22nd, 2018.
Definition / general
  • Least common of the benign cystic lesions of the parotid gland
  • Also called dysgenetic disease
  • Clinically characterized by recurrent, painless swelling of the involved gland(s) which are not associated with any other abnormality
  • Not clear whether this is associated with cystic conditions of the kidney, liver, lung or pancreas
  • Developmental disorder of mainly females with mainly bilateral gland enlargement
Microscopic (histologic) description
  • Classically shows distended lobules composed of epithelial lined cysts imparting a honeycombed or lattice-like appearance
  • Cystic spaces contain eosinophilic material and eosinophilic bodies with concentric and radial patterns
  • No associated inflammatory reaction
  • Origin of the cyst epithelium is thought to be from the intercalated duct
  • Residual islands of salivary glands may be interspersed between the cysts