Salivary glands
Hematolymphoid
Rosai-Dorfman disease


Topic Completed: 1 September 2012

Revised: 29 April 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Rosai-Dorfman disease salivary

Adriana Handra-Luca, M.D.
Page views in 2018: 422
Page views in 2019 to date: 368
Cite this page: Handra-Luca A. Rosai-Dorfman disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsrosaidorfman.html. Accessed July 23rd, 2019.
Definition / general
  • Histiocytic proliferation with emperipolesis in background of plasma cells and lymphocytes
  • First described by Destombes (1965), Rosai and Dorfman (Arch Pathol 1969;87:63)
  • Also called sinus histiocytosis with massive lymphadenopathy
  • Unknown origin but associated with immunologic abnormalities
Clinical features
  • Rarely presents as salivary gland involvement without significant lymphadenopathy
  • Usually long clinical course with exacerbations and remissions and eventual complete remission
  • Primarily submandibular and parotid glands
Case reports
Microscopic (histologic) description
  • Histiocytic proliferation with emperipolesis in background of plasma cells and lymphocytes, with eventually effacement of organ and formation of fibrous bands
Microscopic (histologic) images

Images hosted on other servers:

Emperipolesis, histiocytic proliferation, S100+

Nasal mucosa / cervical lymph nodes

Cytology description
  • Moderate cellularity, large histiocytes, lymphoplasmocytic infiltrate, histiocytic lymphagocytosis
Cytology images

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Cervical lymph nodes

Positive stains
Differential diagnosis
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