Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Salivary glands

Other tumors

Schwannoma


Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 1 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Neural tumor that may arise from facial nerve and present as salivary gland tumor
● Adults or children; often occurs in intranodal parotid gland
● Rarely diagnosed pre-operatively
● Slow growing, usually asymptomatic, neurological signs when associated with nerve compression

Case reports
=========================================================================

● 7 year old boy with slow growing, painless preauricular mass present for 3 years (Kulak Burun Bogaz Ihtis Derg 2008;18:175)
● 67 year old woman with parotid mass (J Laryngol Otol 2009;123:912)
● 70 year old woman with painless swelling of floor of mouth (Ann Diagn Pathol 2012;16:141)
● 75 year old woman with 3 cm tumor of parotid gland (Acta Cytol 2006;50:529)
● Asymptomatic parotid mass diagnosed as facial nerve schwannoma intraoperatively (Am J Otolaryngol 2008;29:126)
● CXPA which occurred in the parotid gland, showing retrograde perineural invasion (Auris Nasus Larynx 2008;35:291)

Treatment
=========================================================================

● Surgery for multiple schwannoma; may recur if incomplete resection

Gross description
=========================================================================

● Encapsulated tumor

Micro images
=========================================================================



Tumor of sublingual gland

Micro description
=========================================================================

● Resembles schwannoma elsewhere; pseudoglandular (J Oral Pathol Med 2006;35:379) and ancient schwannoma variants may be present

Micro images
=========================================================================



Various images


Tumor of sublingual gland shows (left to right): thin fibrous capsule, spindle cells with palisading pattern, residual gland in center of tumor (Alcian blue pH2.5 / PAS), S100+

Cytology description
=========================================================================

● Uniform spindle cells with scant, ill defined cytoplasm and cigar-shaped nuclei; also lymphocytes, foamy histiocytes, Verocay body clusters

Stains
=========================================================================

● S100+, neurofilament-

Differential diagnosis
=========================================================================

● Carcinoma ex-pleomorphic adenoma
Pleomorphic adenoma: may have schwannoma-like features or spindle cells (Rare Tumors 2011;3:e40)

End of Salivary glands > Other tumors > Schwannoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).