Salivary glands
Primary salivary gland neoplasms - benign
Sialadenoma papilliferum


Topic Completed: 1 September 2012

Revised: 29 April 2019

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PubMed Search: Sialadenoma papilliferum salivary

Adriana Handra-Luca, M.D.
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Cite this page: Handra-Luca A. Sialadenoma papilliferum. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandssialadenoma.html. Accessed December 6th, 2019.
Definition / general
  • Rare benign biphasic tumor with exophytic squamous component and endophytic glandular component
  • Well differentiated papillary hyperplastic squamous epithelium covering ductal component of cleft-like cystic spaces lined by cuboidal or columnar epithelium with occasional goblet cells
  • First described by Abrams in 1969 (Cancer 1969;24:1057)
Clinical features
Case reports
Gross description
  • Well circumscribed, round / oval, papillary tumor of mucosal surface
Microscopic (histologic) description
  • Biphasic, with well differentiated papillary hyperplastic squamous epithelium covering ductal component of cleft-like cystic spaces lined by cuboidal or columnar epithelium with occasional goblet cells
  • Variable oncocytes and squamous metaplasia, dysplasia and in situ carcinoma in exophytic component (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:e27)
  • Has malignant counterpart or evolves to mucoepidermoid carcinoma or epithelial myoepithelial carcinoma with high grade carcinoma
Microscopic (histologic) images

Images hosted on other servers:

Floor of mouth tumor


Hard palate cases

Mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum

Positive stains
Electron microscopy description
  • Oncocyte is predominant cell; contains numerous mitochondria, parallel filaments within cell cytoplasm attached by desmosomes (Arch Pathol Lab Med 1986;110:523)
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