Salivary glands

Primary salivary gland neoplasms

Malignant

Sialoblastoma



Last author update: 1 September 2012
Last staff update: 28 December 2022

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PubMed Search: Sialoblastoma salivary glands

Adriana Handra-Luca, M.D., Ph.D.
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Cite this page: Handra-Luca A. Sialoblastoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/salivaryglandssialoblastoma.html. Accessed March 29th, 2024.
Definition / general
Clinical features
  • Childhood epithelial salivary gland tumor; common among the perinatal tumors
  • Occurs in submandibular, parotid or minor salivary glands; also ectopic salivary gland tissue
  • Uni or multinodular, 2 - 7 cm, rapid growth
  • May recur locally or involve regional lymph nodes; also lung metastases
Case reports
Treatment
Microscopic (histologic) description
  • Ductules and solid organoid nests of basaloid cells with fine chromatin and cuboidal epithelial cells
  • 2 histological patterns: favorable pattern with semiencapsulation of benign basaloid cells with intervening stroma; unfavorable pattern with anaplastic basaloid cells, broad pushing to infiltrative periphery and minimal stroma (Ann Diagn Pathol 2006;10:320)
  • Variable necrosis, variable mitotic activity, variable nuclear atypia, no perineurial invasion
Microscopic (histologic) images

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Recurrent and metastatic tumor

Nests of basaloid cells

Cytology description
  • Tight, solid clusters of atypical basaloid cells plus dispersed epithelial and myoepithelial cells with metachromatic magenta hyaline globular material
Positive stains
Differential diagnosis
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