Salivary glands - Sialolipoma

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Salivary glands

Other tumors

Sialolipoma

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 28 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Uncommon lipoma variant composed of mature adipose tissue mixed with acinar, ductal, basal and myoepithelial cells of normal salivary gland
● First described in 2001 by Nagao (Histopathology 2001;38:30)

Clinical features
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● Mean age 61 years, but wide age range at presentation
● Female gender predominance for minor salivary gland location
● Parotid and submandibular glands, hard and soft palate
● May be due to entrapment of salivary gland elements by lipoma
● Benign behavior, no recurrences reported

Case reports
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● Congenital sialolipoma in female infant (Int J Pediatr Otorhinolaryngol 2005;69:429)
● Female newborn with slight facial asymmetry (Head Neck Pathol 2008;2:36)
● 3 year old girl with sialolipoma with diffuse sebaceous differentiation (Pediatr Dev Pathol 2007;10:138)
● 3 year old boy with submandibular gland tumor (J Pediatr Surg 2011;46:408)
● 18 year old man with submandibular sialoangiolipoma (Natl J Maxillofac Surg 2012;3:98)
● 68 year old woman with sensation of "large foreign body" in throat (Case of the Week #49)
● 72 year old woman with painless swelling of hard palate (Head Neck Pathol 2010;4:249)
● 73 year old man with submandibular mass (Indian J Pathol Microbiol 2009;52:379)
● 77 year old woman with submandibular mass (Br J Oral Maxillofac Surg 2008;46:599)

Treatment
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● Surgical excision; no malignant transformation or recurrences (Ann Diagn Pathol 2011;15:6 )

Gross description
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● Well circumscribed, resembles lipoma
● Median 2 cm (range, 1-4 cm)

Gross images
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Well circumscribed tumor

Parotid sialoangiolipoma

Micro description
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● Mature adipose tissue mixed with acinar, ductal, basal and myoepithelial cells of normal salivary gland
● Also duct ectasia with fibrosis, prominent lymphoid infiltrates with nodular aggregates in stroma, oncocytic changes, sebaceous differentiation
● Vascular variant is sialoangiolipoma

Micro images
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Case of the week #49:

Peripheral lipomatous tissue with central salivary gland elements

Lipoma like areas

Acini and dilated ducts

Ducts with fibrosis of wall infiltrated by lymphocytes

Lower lip tumor

Submandibular sialoangiolipoma

Parotid sialoangiolipoma

End of Salivary glands > Other tumors > Sialolipoma

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