Reviewers: Fatima Aly, M.D. (see Reviewers page)
Revised: 9 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Systemic autoimmune disease presenting typically with xerostomia (dry mouth), keratoconjunctivitis sicca (dry eyes), rheumatoid arthritis, hypergammaglobulinemia
● Occasionally involving lymph nodes, lung, kidney, bone marrow, skeletal muscle, skin, liver
● Associated with autoimmune thyroiditis, systemic vasculitis, MALT lymphomas
● Variable amyloid deposition outside the salivary glands
● Requires presence of a number of clinical and pathologic features
● Adequate biopsy of minor salivary glands (5 or more glands) with a focus score of more than 1 focus/4mm square has been proposed as the diagnostic criteria
● Extensive lymphoid infiltrate with germinal centers, often interstitial fibrosis and acinar atrophy
● Usually no/rare epimyoepithelial islands in minor salivary glands, although may appear in major salivary glands
● Non-specific chronic sialadenitis: may show diffuse atrophy of glandular epithelium in lobes or entire glands, duct dilatation and interstitial fibrosis; inflammatory infiltrate may be focal but is commonly interstitial and scattered in pattern
End of Salivary Glands > Inflammation > Sjogren’s syndrome
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