Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Salivary glands

Inflammation

Sjogren’s syndrome


Reviewers: Fatima Aly, M.D. (see Reviewers page)
Revised: 9 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

General
=========================================================================

● Systemic autoimmune disease presenting typically with xerostomia (dry mouth), keratoconjunctivitis sicca (dry eyes), rheumatoid arthritis, hypergammaglobulinemia
● Occasionally involving lymph nodes, lung, kidney, bone marrow, skeletal muscle, skin, liver
● Associated with autoimmune thyroiditis, systemic vasculitis, MALT lymphomas
● Variable amyloid deposition outside the salivary glands

Diagnosis
=========================================================================

● Requires presence of a number of clinical and pathologic features
● Adequate biopsy of minor salivary glands (5 or more glands) with a focus score of more than 1 focus/4mm square has been proposed as the diagnostic criteria

Micro description
=========================================================================

● Extensive lymphoid infiltrate with germinal centers, often interstitial fibrosis and acinar atrophy
● Usually no/rare epimyoepithelial islands in minor salivary glands, although may appear in major salivary glands

Differential diagnosis
=========================================================================

● Non-specific chronic sialadenitis: may show diffuse atrophy of glandular epithelium in lobes or entire glands, duct dilatation and interstitial fibrosis; inflammatory infiltrate may be focal but is commonly interstitial and scattered in pattern

End of Salivary Glands > Inflammation > Sjogren’s syndrome


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).