Skin inflammatory (nontumor)
Panniculitis
Alpha-1-antitrypsin deficiency panniculitis


Topic Completed: 1 July 2011

Revised: 2 April 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Alpha-1-antitrypsin deficiency panniculitis

Mowafak Hamodat, M.B.Ch.B., M.Sc.
Page views in 2018: 260
Page views in 2019 to date: 173
Cite this page: Hamodat M Alpha-1-antitrypsin deficiency panniculitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumora1antitrypsin.html. Accessed August 18th, 2019.
Clinical features
  • Patients have low serum alpha-1-antitrypsin
  • Cutaneous lesions are diffuse indurated erythematous plaques or nodules that drain serosangineous fluid, on extensor surfaces of arms, legs, thighs, chest, back and abdomen
  • Also pulmonary effusion, embolism edema and anasarca
Case reports
Clinical images

Images hosted on other servers:

Ulcer on upper extremity

Microscopic (histologic) description
  • Early: diffuse neutrophilic infiltrate through dermis into subcutaneous septa, followed by destruction of collagen, reduction of inflammatory cells, detachment of lobules of fat from fibrous septa in a background of neutrophils
  • Draining lesions have channels lined by squamous epithelium
  • Late: extensive scarring of dermis and subcutis
Positive stains
  • Immunoglobulin IgM and C3 may be found in blood vessel walls
Differential diagnosis
  • Bacterial cellulitis: infectious etiology
Back to top