Skin inflammatory (nontumor)
Dermal collagen and elastic tissue alterations, and cutaneous deposits

Author: Cecilia Rosales, M.D. (see Authors page)

Revised: 17 October 2018, last major update July 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Anetoderma

Page views in 2017: 810
Page views in 2018 to date: 978
Cite this page: Rosales, C. Anetoderma. website. Accessed December 18th, 2018.
Definition / general
  • Benign disorder of focal loss of dermal elastic tissue, causing focal flaccid or saclike skin
  • Either primary (idiopathic) arising in normal skin, or secondary arising at site of previous skin lesions
  • Greek: Anetos means slack
  • Acquired purely cutaneous disorder
  • Most common in young adults, onset most often in second decade
  • Affects upper trunk and proximal arms; may be widespread
  • Affect both sexes equally; rare familial variant
Clinical features
  • Erythematous macules and urticarial plaques, progressing to flaccid, easily reduced papules
  • Also fine, diffuse wrinkling
  • May be accompanied by herniation into subcutaneous fat
Case reports
Clinical images

Images hosted on other servers:

Lesion of lower leg

Lesions of shoulders and upper back

Microscopic (histologic) description
  • No abnormality on H&E
  • Elastic stains show no / marked reduction in elastic fibers of papillary and mid-reticular dermis
  • Early lesions: variable perivascular and periadnexal mixed inflammatory infiltrate
Microscopic (histologic) images

Images hosted on other servers:

Faintly eosinophilic separated collagen bundles in upper dermis

Minimal dermal perivascular chronic inflammatory cells infiltrate