Skin-nontumor / Clinical dermatology
Other dermatoses
Annular elastolytic giant cell granuloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 June 2016, last major update July 2011

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Annular elastolytic giant cell granuloma

Cite this page: Annular elastolytic giant cell granuloma. website. Accessed October 26th, 2016.
Definition / General
  • Erythematous or brown annular infiltrate in face, neck or dorsa of hands of elderly or heavily sun-exposed individuals
  • May be a variant of granuloma annulare
  • Also called O’Brien’s actinic granuloma or Miescher’s granuloma
Case Reports
Clinical Images

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Neck lesion

Micro Description
  • Dermis in region of rim has histiocytes and foreign body giant cells engulfing elastotic fibers (elastoclasis)
  • Also variable lymphocytes, plasma cells and eosinophils
  • Usually no necrobiosis, no increased dermal mucin
Micro Images

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Granulomatous infiltrate of multinucleated giant cells in upper reticular dermis

Elastophagocytosis and loss of elastic
fibers in center of lesion (orcein staining)

Differential Diagnosis
  • Granuloma annulare and necrobiosis lipoidica usually have necrobiosis, increased dermal mucin