Annular elastolytic giant cell granuloma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 18 July 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Erythematous or brown annular infiltrate in face, neck or dorsa of hands of elderly or heavily sun-exposed individuals
● May be a variant of granuloma annulare
● Also called O’Brien’s actinic granuloma or Miescher’s granuloma
● 45 year old woman with growing lesion in neck (Dermatol Online J 2011;17:7)
Raised forehead lesion
● Dermis in region of rim has histiocytes and foreign body giant cells engulfing elastotic fibers (elastoclasis)
● Also variable lymphocytes, plasma cells and eosinophils
● Usually no necrobiosis, no increased dermal mucin
Granulomatous infiltrate of multinucleated giant cells in upper reticular dermis
Elastophagocytosis and loss of elastic fibers in center of lesion (orcein staining)
● Granuloma annulare and necrobiosis lipoidica usually have necrobiosis, increased dermal mucin
End of Skin-nontumor > Other dermatoses > Annular elastolytic giant cell granuloma
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