Skin-nontumor / Clinical dermatology
Granulomatous but noninfectious disorders
Annular elastolytic giant cell granuloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 May 2017, last major update July 2011

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PubMed Search: Annular elastolytic giant cell granuloma

Cite this page: Annular elastolytic giant cell granuloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorannularelastolytic.html. Accessed July 22nd, 2017.
Definition / general
  • Erythematous or brown annular infiltrate in face, neck or dorsa of hands of elderly or heavily sun-exposed individuals
  • May be a variant of granuloma annulare
Terminology
  • Also called O’Brien’s actinic granuloma or Miescher’s granuloma
Case reports
Clinical images

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Neck lesion

Microscopic (histologic) description
  • Dermis in region of rim has histiocytes and foreign body giant cells engulfing elastotic fibers (elastoclasis)
  • Also variable lymphocytes, plasma cells and eosinophils
  • Usually no necrobiosis, no increased dermal mucin
Microscopic (histologic) images

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Granulomatous infiltrate of multinucleated giant cells in upper reticular dermis

Elastophagocytosis and loss of elastic
fibers in center of lesion (orcein staining)

Differential diagnosis
  • Granuloma annulare and necrobiosis lipoidica usually have necrobiosis, increased dermal mucin