Skin inflammatory (nontumor)
Pigmentary disorders
Argyria


Topic Completed: 1 July 2011

Revised: 2 April 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Argyria
Page views in 2018: 419
Page views in 2019 to date: 218
Cite this page: Rosales C Argyria. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorargyria.html. Accessed June 15th, 2019.
Definition / general
  • Permanent discoloration of skin due to dietary, medicinal or industrial exposure to silver compounds
  • Silver deposition in skin and mucous membranes, liver, spleen, adrenal, muscle and brain
  • Silver deposits cause pigmentation of basement membranes of adnexal structures
Clinical features
  • Initially present in gingiva as slate blue line due to metallic silver and silver sulfide
  • Cutaneous manifestations follow a sun-exposed distribution
  • Nails can also be involved
  • Laser treatment may be useful (Int J Dermatol 2011;50:751)
Clinical images

Images hosted on other servers:

Various images

Microscopic (histologic) description
  • Silver granules in vascular and adnexal basement membranes and adjacent to dermal elastic fibers
  • Granules are brown-black
Microscopic (histologic) images

Images hosted on other servers:

Tiny, gray-brown-black granules in dermis and concentrated near eccrine glands

Electron microscopy description
  • Membrane bound granules within macrophages, lysosomes or free within dermis
Back to top