Skin inflammatory (nontumor)
Panniculitis
Cytophagic histiocytic panniculitis


Topic Completed: 1 July 2011

Revised: 2 April 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Cytophagic histiocytic panniculitis

Mowafak Hamodat, M.B.Ch.B., M.Sc.
Page views in 2018: 350
Page views in 2019 to date: 423
Cite this page: Hamodat M Cytophagic histiocytic panniculitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorcytophagichistiocyticpanniculitis.html. Accessed December 12th, 2019.
Definition / general
Terminology
  • Panniculitis associated with hemophagocytic syndrome
Etiology
  • Associated with CMV, EBV, HIV, bacteria, fungi and parasites
  • Occurs post-bone marrow transplant, with SLE, as adverse reaction to interferon alpha therapy
  • Associated with T cell lymphoma
  • Presents with spiking fever, erythematous subcutaneous skin nodules, anemia, leukopenia
  • May be fatal with multisystemic involvement
Clinical features
  • Erythematosus to violaceous or hemorrhagic nodules, often in lower limbs and trunk
  • Ulceration with localized or generalized edema
Microscopic (histologic) description
  • Lobular or partially septal distribution of florid lobular panniculitis, with large histiocytes containing eosinophilic cytoplasm; also neutrophils and lymphocytes
  • Red cell extravasation typically present with frank hemorrhage
  • Erythrophagocytosis, phagocytosis of lymphocytes or nuclear debris
  • Enlarged histiocytes may be described as "bean bag cell"
  • Usually no giant cells / granulomas
Microscopic (histologic) images

Images hosted on other servers:

11 year old girl with perforin gene mutation

Differential diagnosis
  • Angiocentric lymphoma
  • Cutaneous Rosai Dorfman disease
  • Subcutaneous T cell panniculitis lymphoma
Back to top