Skin-nontumor / Clinical dermatology
Other dermatoses
Drug reaction

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 24 June 2016, last major update July 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Drug reaction [title]

Cite this page: Drug reaction. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumordrugreaction.html. Accessed December 11th, 2016.
Definition / General
  • May cause urticaria, erythema multiforme, erythema nodosum, folliculitis, pustules, purpura, hyperpigmentation or vasculitis
  • Procainamide may induce SLE-like disease
  • Anti-cancer drugs may cause acute necrotizing changes in sweat glands (neutrophilic eccrine hidradenitis or syringosquamous metaplasia)
  • Drug induced coma may cause necrosis of eccrine sweat coils and other adnexae, also epidermis
  • Other drugs causing cutaneous reactions include gold salts, thiazides, antimalarial drugs, color film developers, tetracycline, barbiturates, phenolphthalein

  • Fixed drug reaction: repeated administration causes recurrence of red-brown patch in same location, variable bullae
Sites
  • Genitalia and face
Treatment
  • Discontinue drug
Clinical Images

Images hosted on PathOut servers:

Breast skin, courtesy of Mark R. Wick, M.D.


Images hosted on other servers:

14 year old boy with reaction to sulfasalazine

Micro Description
  • Eosinophils and marked vascular wall thickening
  • May cause granulomatous infiltrate
  • Also vacuolar interface changes and often lymphocytic exocytosis, dyskeratotic keratinocytes, parakeratosis with eosinophils and plasma cells in dermis
Micro Images

Images hosted on PathOut servers:

Breast skin, courtesy of Mark R. Wick, M.D.


Images hosted on other servers:

Lichenoid drug reaction

Differential Diagnosis
Additional References