Skin inflammatory (nontumor)
Folliculitis, perifolliculitis and disease of skin appendages
Eosinophilic pustular folliculitis

Author: Mowafak Hamodat, M.D., M.Sc. (see Authors page)

Revised: 17 October 2018, last major update July 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Eosinophilic pustular folliculitis

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Cite this page: Hamodat, M. Eosinophilic pustular folliculitis. website. Accessed January 21st, 2019.
Definition / general
  • Associated with HIV in U.S.
  • Sudden onset of disseminated pustules on trunk
  • Also called Ofuji disease, eosinophilic folliculitis
  • Typically recurrent disease and spontaneous resolution within months to several years
  • Associated with HIV, lymphoma (non-Hodgkin and Hodgkin), myelodysplastic syndrome, eosinophilic cellulitis and nevoid basal cell carcinoma syndrome
Clinical features
  • Three variants:
    • Classic (Ofuji disease)
    • Immunosuppression / HIV associated
    • Infancy associated

  • Clinically resembles acne
  • No known cause
Clinical images

Images hosted on other servers:

Widespread hyperpigmented patches

Various images

Microscopic (histologic) description
  • Eosinophilic infiltration of hair follicle; follicular epithelium is spongiotic, adjacent dermis has lymphocytic and eosinophilic infiltrate
  • Superficial dermal perivascular mononuclear and eosinophilic infiltrate
  • Follicular mucinosis may rarely be seen
  • Healing is associated with postinflammatory hyperpigmentation
Microscopic (histologic) images

Images hosted on other servers:

Eosinophilic folliculitis