Skin-nontumor / Clinical Dermatology - Eosinophilic pustular folliculitis

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Other dermatoses

Eosinophilic pustular folliculitis

Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns, Canada (see Reviewers page)
Revised: 27 July 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Associated with HIV in US
● Sudden onset of disseminated pustules on trunk

Terminology
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● Also called Ofuji disease, eosinophilic folliculitis

Epidemiology
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● Typically recurrent disease and spontaneous resolution within months to several years
● Associated with HIV, lymphoma (non Hodgkin and Hodgkin), myelodysplastic syndrome, eosinophilic cellulitis and nevoid basal cell carcinoma syndrome

Clinical features
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● Three variants: classic (Ofuji disease), immunosuppression/HIV associated and infancy associated
● Clinically resembles acne
● No known cause

Clinical images
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Widespread hyperpigmented patches

Various images

Micro description
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● Eosinophilic infiltration of hair follicle; follicular epithelium is spongiotic, adjacent dermis has lymphocytic and eosinophilic infiltrate
● Superficial dermal perivascular mononuclear and eosinophilic infiltrate
● Follicular mucinosis may rarely be seen
● Healing is associated with post-inflammatory hyperpigmentation

Micro images
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Various images

End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Eosinophilic pustular folliculitis

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