Skin - nontumor / clinical dermatology
Infectious disorders
Epidermodysplasia verruciformis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 29 August 2018, last major update July 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Epidermodysplasia verruciformis

Cite this page: Pernick, N. Epidermodysplasia verruciformis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorepidermodysplasia.html. Accessed September 24th, 2018.
Definition / general
  • Disorder of multiple flat warts on face or distal extremities, often disseminated throughout the body
Etiology
Clinical features
  • 30 - 50% progress to invasive squamous cell carcinoma, mean age 31 years
  • Equivocal cases are best distinguished by histology and viral testing, in context of clinical setting
  • Flat, skin colored, red or hyperpigmented papules resembling flat warts or scaly brown pityriasis versicolor-like macules and patches
  • Also seborrheic keratosis-like
Treatment
  • Excision or locally destructive methods
Clinical images

Images hosted on other servers:

Various images

Arm

Microscopic (histologic) description
  • Classic features are mild to moderate acanthosis and hyperkeratosis
  • Large cells with blue-gray cytoplasm, perinuclear halos, often dysplastic changes, particularly post kidney transplantation (J Cutan Pathol 2002;29:480)
  • More commonly has irregular granular layer with rare perinuclear halos
Microscopic (histologic) images

Images hosted on other servers:

Various images

Characteristic enlarged keratinocytes with blue-gray pallor; no significant keratinocytic atypia, pleomorphism or mitotic figures