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Skin-nontumor / Clinical Dermatology

Other dermatoses

Hemochromatosis


Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC (see Reviewers page)
Revised: 26 August 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Multisystemic disorder of iron metabolism with cutaneous manifestations in up to 90% of patients
● Typically bronze pigmentation in the forehead and malar area ("bronzed diabetes"), may also be slate-gray
● Pigmentation fades as iron levels decline
● See also Liver chapter

Treatment
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● Phlebotomy

Micro description
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● Thinning of the epidermis, increased melanin pigment in the basal layer
● Golden brown granules of hemosiderin in the basement membrane region of sweat glands and in macrophages in loose connective tissue stroma of these glands
● A small amount of hemosiderin is associated with sebaceous glands and their stroma
● Small specks of hemosiderin can be seen in the epidermis with Pearl’s stain

Additional references
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eMedicine

End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Hemochromatosis


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