Skin-nontumor / Clinical dermatology
Infectious disorders
Hepatitis C

Author: Mowafak Hamodat MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 25 May 2016, last major update September 2010

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Skin + Hepatitis C [title]

Cite this page: Hepatitis C. website. Accessed September 24th, 2018.
Definition / general
  • Previously major cause of transfusion-associated hepatitis that occasionally causes various cutaneous eruptions
  • Constitutes most cases previously called nonA, nonB hepatitis
  • Transmitted intravenously; associated with IV drug abuse, organ transplant, hemodialysis and health care workers
Clinical features
  • Combined pegylated interferon (either alfa-2a or -2b) and ribavirin
Clinical images

Images hosted on other servers:

Palpable purpura

Treatment-related skin disorders:

Skin rash, psoriasis and eczema

Microscopic (histologic) description
  • Common features are neutrophilic, lymphocytic and granulomatous vasculitis and pauci-inflammatory subtypes
  • Also sterile neutrophilic folliculitis, palisading granulomatous inflammation, neutrophilic dermatoses, pyoderma gangrenosum, interface dermatitis and lobular panniculitis, leukocytoclastic vasculitits (J Am Acad Dermatol 2010;63:259)
Positive stains
  • Perivascular deposits of C3 and IgA by immunofluorescence
Additional references