Skin inflammatory (nontumor)
Infectious disorders
Hepatitis C


Topic Completed: 1 September 2010

Revised: 1 April 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Skin + Hepatitis C [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M Hepatitis C. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorhepatitisC.html. Accessed August 21st, 2019.
Definition / general
  • Previously major cause of transfusion-associated hepatitis that occasionally causes various cutaneous eruptions
Terminology
  • Constitutes most cases previously called nonA, nonB hepatitis
Epidemiology
  • Transmitted intravenously; associated with IV drug abuse, organ transplant, hemodialysis and health care workers
Clinical features
Treatment
  • Combined pegylated interferon (either alfa-2a or -2b) and ribavirin
Clinical images

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Palpable purpura



Treatment-related skin disorders

Skin rash, psoriasis and eczema

Microscopic (histologic) description
  • Common features are neutrophilic, lymphocytic and granulomatous vasculitis and pauci-inflammatory subtypes
  • Also sterile neutrophilic folliculitis, palisading granulomatous inflammation, neutrophilic dermatoses, pyoderma gangrenosum, interface dermatitis and lobular panniculitis, leukocytoclastic vasculitits (J Am Acad Dermatol 2010;63:259)
Positive stains
  • Perivascular deposits of C3 and IgA by immunofluorescence
Additional references
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