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Skin-nontumor / Clinical Dermatology

Other dermatoses

Ichthyosis


Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns, Canada (see Reviewers page)
Revised: 31 July 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Disorder of epidermal maturation in which skin resembles fish scales
● Associated with excessive keratin buildup due to a desquamation defect, leading to retention of abnormally formed scale
● Usually apparent at birth
● In adults, is associated with malignancies (lymphoma, carcinoma of bronchus, breast and cervix), sarcoidosis, lupus and drugs
Ichthyosis vulgaris: common type
Lamellar ichthyosis: rare inherited skin condition of newborn with shedding of plate-like layers of skin
X linked variant: deficiency in steroid sulfatase, which removes proadhesive cholesterol sulfate from intracellular spaces

Clinical description
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● Skin resembles fish scales; rough scaly patches and plaques

Clinical images
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Lamellar ichthyosis

Micro description
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● Increased stratum corneum with loss of normal basket weave pattern, minimal inflammation
● Loss of granular layer in ichthyosis vulgaris

Virtual slides
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Lamellar ichthyosis

Additional references
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X-linked variant
Lamellar ichthyosis
Ichthyosis vulgaris

End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Ichthyosis


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