Skin inflammatory (nontumor)
Langerhans cells

Author: Mowafak Hamodat MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 11 October 2018, last major update August 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Langerhans cells [title]

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Cite this page: Hamodat, M. Langerhans cells. website. Accessed January 17th, 2019.
Definition / general
  • Bone marrow derived dendritic cells that present antigens to T cells
  • Scattered in upper squamous layer and in the dermis, but difficult to see on H&E
Microscopic (histologic) images

Images hosted on other servers:

S100+ cells in skin

Positive stains
  • S100, CD1a; also IgG Fc receptor, C3
Electron microscopy description
  • Have characteristic Birbeck granules (rod shaped structure with zipper-like striations, often with bulbous end)
Electron microscopy images

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Birbeck granules

Additional references