Skin nontumor
Langerhans cells

Topic Completed: 1 August 2010

Minor changes: 7 April 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Langerhans cells [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M. Langerhans cells. website. Accessed May 28th, 2020.
Definition / general
  • Bone marrow derived dendritic cells that present antigens to T cells
  • Scattered in upper squamous layer and in the dermis, but difficult to see on H&E
Microscopic (histologic) images

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S100+ cells in skin

Positive stains
  • S100, CD1a; also IgG Fc receptor, C3
Electron microscopy description
  • Have characteristic Birbeck granules (rod shaped structure with zipper-like striations, often with bulbous end)
Electron microscopy images

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Birbeck granules

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