Skin-nontumor / Clinical dermatology
Langerhans cells

Author: Mowafak Hamodat MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 19 May 2016, last major update August 2010

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Langerhans cells [title]

Cite this page: Langerhans cells. website. Accessed October 26th, 2016.
Definition / General
  • Bone marrow derived dendritic cells that present antigens to T cells
  • Scattered in upper squamous layer and in the dermis, but difficult to see on H&E
Micro Images

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S100+ cells in skin

Positive Stains
  • S100, CD1a; also IgG Fc receptor, C3
Electron Microscopy Description
  • Have characteristic Birbeck granules (rod shaped structure with zipper-like striations, often with bulbous end)
Electron Microscopy Images

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Birbeck granules

Additional References