Skin inflammatory (nontumor)
General
Langerhans cells


Topic Completed: 1 August 2010

Revised: 26 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Langerhans cells [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M Langerhans cells. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorlangerhans.html. Accessed July 17th, 2019.
Definition / general
  • Bone marrow derived dendritic cells that present antigens to T cells
  • Scattered in upper squamous layer and in the dermis, but difficult to see on H&E
Microscopic (histologic) images

Images hosted on other servers:

S100+ cells in skin

Positive stains
  • S100, CD1a; also IgG Fc receptor, C3
Electron microscopy description
  • Have characteristic Birbeck granules (rod shaped structure with zipper-like striations, often with bulbous end)
Electron microscopy images

Images hosted on other servers:

Birbeck granules

Additional references
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