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Skin-nontumor / Clinical Dermatology

General

Langerhans cells


Reviewer: Mowafak Hamodat MB.CH.B, MSc., FRCPC, Memorial University of Newfoundland (see Reviewers page)
Revised: 24 August 2011, last major update August 2010
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Bone marrow derived dendritic cells that present antigens to T cells
● Scattered in upper squamous layer and in the dermis, but difficult to see on H&E

Micro images
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S100+ cells in skin

Positive stains
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● S100, CD1a; also IgG Fc receptor, C3

Electron microscopy
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● Have characteristic Birbeck granules (rod shaped structure with zipper-like striations, often with bulbous end)

Electron microscopy images
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Birbeck granules

Additional references
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Wikipedia, American Academy of Dermatology

End of Skin-nontumor / Clinical Dermatology > General > Langerhans cells


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