Skin inflammatory (nontumor)
Lichenoid and interface reaction patterns
Lichenoid dermatitis

Topic Completed: 1 August 2011

Revised: 26 March 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Lichenoid dermatitis [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
Page views in 2018: 5,594
Page views in 2019 to date: 5,456
Cite this page: Hamodat M Lichenoid dermatitis. website. Accessed October 16th, 2019.
Definition / general
  • A histological pattern, not a distinct clinical entity
  • Due to drug eruption, actinic keratosis, lupus erythematosus, acute graft versus host disease, regressing melanoma and dermatofibroma
  • May be a delayed hypersensitivity reaction
  • May present as a neoplasm
Microscopic (histologic) description
  • Dense, bandlike lymphocytic infiltrate in dermis that obscures dermoepidermal junction
  • Cytoplasmic vacuolization of basal keratinocytes with a brightly eosinophilic cytoplasm; the nucleus becomes extruded to become round/oval eosinophilic bodies (colloid bodies)
  • Regenerated epithelium has a disorderly basement membrane
  • May have large cell acanthoma or solar lentigo within the lesion
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