Skin inflammatory (nontumor)
Lichenoid and interface reaction patterns
Lichenoid dermatitis

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 15 October 2018, last major update August 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Lichenoid dermatitis [title]

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Cite this page: Hamodat, M. Lichenoid dermatitis. website. Accessed February 18th, 2019.
Definition / general
  • A histological pattern, not a distinct clinical entity
  • Due to drug eruption, actinic keratosis, lupus erythematosus, acute graft versus host disease, regressing melanoma and dermatofibroma
  • May be a delayed hypersensitivity reaction
  • May present as a neoplasm
Microscopic (histologic) description
  • Dense, bandlike lymphocytic infiltrate in dermis that obscures dermoepidermal junction
  • Cytoplasmic vacuolization of basal keratinocytes with a brightly eosinophilic cytoplasm; the nucleus becomes extruded to become round/oval eosinophilic bodies (colloid bodies)
  • Regenerated epithelium has a disorderly basement membrane
  • May have large cell acanthoma or solar lentigo within the lesion