Skin inflammatory (nontumor)
Dermal collagen and elastic tissue alterations, and cutaneous deposits
Malignant atrophic papulosis

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 17 October 2018, last major update August 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Malignant atrophic papulosis

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Cite this page: Hamodat, M. Malignant atrophic papulosis. website. Accessed January 21st, 2019.
Definition / general
  • Intimal proliferation of deep-seated arterioles which causes infarcts
  • Dego's disease: variant causing a lethal syndrome, involving small bowel, heart, lungs, kidney, bladder and liver
  • Also benign and familiar variants
Clinical features
  • Discrete small patches composed of a central zone with a depressed white, porcelain like appearance and a fine scale surrounded by a narrow red or violaceous rim associated with a fine telangiectasia
  • Skin lesions affect the trunk and proximal extremity
Microscopic (histologic) description
  • Epidermis is hyperkeratotic and atrophic
  • Wedge shaped dermal infarct with the base parallel to the surface epithelium
  • Pale in color, relatively acellular
  • Mucin deposition common
  • Older lesions are frequently ulcerated
  • Vessels adjacent to and deep to the infarct show a perivascular lymphocytic infiltrate
  • Endovasculitis in dermal vessels with endothelial cell hyperplasia and complicated by thrombosis
  • Panniculitis mimicking lupus erythematosus profundus has been described
  • Microscopic examination of bowel reveals transmural intestinal inflammation with ulceration and hemorrhage
Differential diagnosis
Additional references