Skin-nontumor / Clinical dermatology
Merkel cells

Author: Mowafak Hamodat MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 19 May 2016, last major update August 2010

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Merkel cells [title]

Cite this page: Merkel cells. website. Accessed April 23rd, 2017.
Definition / General
  • Difficult to see with H&E or special stains
  • Concentrated in skin of digits, finger pads, proximal nail folds, palms, dorsum of feet, lips, hard palate
  • More common in outer root sheath of hair follicles and tactile hair discs
Diagrams / Tables

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Skin and Merkel cells

Positive Stains
Electron Microscopy Description
  • Dense core neurosecretory-type granules in cytoplasm beneath cell membrane or within unmyelinated neurites
  • Anchored to adjacent keratinocytes by spinous processes
Additional References