Skin nontumor
Merkel cells

Topic Completed: 1 August 2010

Minor changes: 7 April 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Merkel cells [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
Page views in 2019: 410
Page views in 2020 to date: 165
Cite this page: Hamodat M. Merkel cells. website. Accessed May 29th, 2020.
Definition / general
  • Difficult to see with H&E or special stains
  • Concentrated in skin of digits, finger pads, proximal nail folds, palms, dorsum of feet, lips, hard palate
  • More common in outer root sheath of hair follicles and tactile hair discs
Diagrams / tables

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Skin and Merkel cells

Positive stains
Electron microscopy description
  • Dense core neurosecretory type granules in cytoplasm beneath cell membrane or within unmyelinated neurites
  • Anchored to adjacent keratinocytes by spinous processes
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