Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Skin-nontumor / Clinical Dermatology

General

Merkel cells


Reviewer: Mowafak Hamodat MB.CH.B, MSc., FRCPC, Memorial University of Newfoundland (see Reviewers page)
Revised: 24 August 2011, last major update August 2010
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
=========================================================================

● Difficult to see with H&E or special stains
● Concentrated in skin of digits, finger pads, proximal nail folds, palms, dorsum of feet, lips, hard palate
● More common in outer root sheath of hair follicles and tactile hair discs

Drawing
=========================================================================


Skin and Merkel cells

Positive stains
=========================================================================

● NSE, neurofilament, keratin

Electron microscopy
=========================================================================

● Dense core neurosecretory-type granules in cytoplasm beneath cell membrane or within unmyelinated neurites
● Anchored to adjacent keratinocytes by spinous processes

Additional references
=========================================================================

Wikipedia

End of Skin-nontumor / Clinical Dermatology > General > Merkel cells


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).