Skin inflammatory (nontumor)
Infectious disorders
Molluscum contagiosum

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 18 October 2018, last major update March 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Molluscum contagiosum [title]

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Cite this page: Hamodat, M. Molluscum contagiosum. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumormolluscum.html. Accessed January 21st, 2019.
Definition / general
  • Infectious disorder caused by molluscum contagiosum poxvirus
  • Multiple nodules on skin, trunk or anogenital region, due to skin to skin contact or sexual transmission
Clinical features
  • Multiple firm, pruritic, pink-tan nodules, up to 4 mm, with central cores containing white keratinous material
Clinical images

Images hosted on PathOut servers:

Breast skin, courtesy of Dr. Mark R. Wick


Images hosted on other servers:

Raised, firm, flesh colored nodules

Microscopic (histologic) description
  • Lobulated endophytic hyperplasia that produces a circumscribed intradermal pseudotumor
  • Molluscum bodies are present (large cells with cytoplasmic, faintly granular eosinophilic inclusions that displace nuclei and contain viral particles); made more conspicuous with Lendrum’s phloxine tartrazine reaction
  • May have intense dermal lymphocytic infiltrate that suggests lymphoma
  • Rarely metaplastic ossification
Microscopic (histologic) images

Images hosted on PathOut servers:

Breast skin, courtesy of Dr. Mark R. Wick

Abdominal skin of 29 year old man, contributed by Dr. Julia Braza

Contributed by Dr. Angel Fernandez-Flores, Ph.D.



Images hosted on other servers:

H&E

Contributed by Dr. Mowafak Hamodat, MB.CH.B, MSc., FRCPC