Skin inflammatory (nontumor)
Lichenoid and interface reaction patterns
Pityriasis lichenoides et varioliformis acuta


Topic Completed: 1 August 2011

Revised: 26 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Pityriasis lichenoides

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M Pityriasis lichenoides et varioliformis acuta. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorpleva.html. Accessed October 16th, 2019.
Definition / general
  • Also called PLEVA, Mucha-Habermann disease
  • Overlaps with pityriasis lichenoides chronica
  • Sudden onset of crops of small, ulcerated papules on trunk
  • May heal with superficial scarring resembling variola (smallpox)
Microscopic (histologic) description
  • Acute lesion shows epidermal changes with much exaggerated scale; marked inter- and intracellular edema accompanied by keratinocyte necrosis and interface changes
  • Exocytosis is usually prominent and intraepidermal red blood cells are characteristic
  • Upper dermis is edematous and contains wedge shape of lymphocytes and histiocytes, usually perivascular, varies from sparse to dense; prominent red cell extravasation
Additional references
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