Skin inflammatory (nontumor)
Spongiotic, psoriasiform and pustular reaction patterns
Prurigoform acanthosis

Topic Completed: 1 August 2011

Revised: 26 March 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Acanthosis [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M Prurigoform acanthosis. website. Accessed August 24th, 2019.
Definition / general
  • A chronic spongiotic dermatitis due to sustained skin irritation, often from rubbing or scratching
Microscopic (histologic) description
  • Epidermis shows hyperkeratosis, acanthosis and pseudoepitheliomatous hyperplasia
  • Sub-epidermal fibrin deposition and mild spongiosis with dermal scarring
  • Dermis shows vascular hyperplasia with dilated vessels in papillary dermis and reticular dermis
  • New vessel formation with perivascular, mild infiltrate of lymphocytes, some histiocytes, plasma cells and occasional eosinophils; mast cells are normal in number
  • Lymphoid follicles may be seen
  • Nerves may appear normal, increased in number or hyperplastic
Differential diagnosis
  • Cutaneous T cell lymphoma, hypertrophic actinic keratosis (atypia), early keratoacanthoma (atypia)
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