Skin-nontumor / Clinical dermatology
Other dermatoses
Prurigoform acanthosis

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 20 July 2016, last major update August 2011

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PubMed Search: Acanthosis [title]

Definition / General
  • A chronic spongiotic dermatitis due to sustained skin irritation, often from rubbing or scratching
Micro Description
  • Epidermis shows hyperkeratosis, acanthosis and pseudoepitheliomatous hyperplasia
  • Sub-epidermal fibrin deposition and mild spongiosis with dermal scarring
  • Dermis shows vascular hyperplasia with dilated vessels in papillary dermis and reticular dermis
  • New vessel formation with perivascular, mild infiltrate of lymphocytes, some histiocytes, plasma cells and occasional eosinophils; mast cells are normal in number
  • Lymphoid follicles may be seen
  • Nerves may appear normal, increased in number or hyperplastic
Differential Diagnosis
  • Cutaneous T cell lymphoma, hypertrophic actinic keratosis (atypia), early keratoacanthoma (atypia)