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Other dermatoses

Prurigoform acanthosis

Reviewer: Mowafak Hamodat MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns (Canada) (see Reviewers page)
Revised: 1 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● A chronic spongiotic dermatitis due to sustained skin irritation, often from rubbing or scratching

Micro description

● Epidermis shows hyperkeratosis, acanthosis and pseudoepitheliomatous hyperplasia
● Sub-epidermal fibrin deposition and mild spongiosis with dermal scarring
● Dermis shows vascular hyperplasia with dilated vessels in papillary dermis and reticular dermis
● New vessel formation with perivascular, mild infiltrate of lymphocytes, some histiocytes, plasma cells and occasional eosinophils; mast cells are normal in number
● Lymphoid follicles may be seen
● Nerves may appear normal, increased in number or hyperplastic

Differential diagnosis

● Cutaneous T cell lymphoma, hypertrophic actinic keratosis (atypia), early keratoacanthoma (atypia)

End of Skin-nontumor > Other dermatoses > Prurigoform acanthosis

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