Skin inflammatory (nontumor)
Dermal collagen and elastic tissue alterations, and cutaneous deposits
Scleredema of Buschke

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 17 October 2018, last major update August 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Scleredema of Buschke

Page views in 2017: 772
Page views in 2018 to date: 940
Cite this page: Hamodat, M. Scleredema of Buschke. website. Accessed December 18th, 2018.
Definition / general
  • Nonpitting, woody induration of upper back skin; associated with diabetes
  • Rare primary mucinosis that presents with non pitting indurated edema and associated dermal hardening in the absence of any clinical abnormality
  • After viral infection, especially UTI or insidious onset with no prior acute illness
  • Occasionally associated with paraproteinemia, secondary hyperparathyroidism, rheumatoid arthritis, Sjogren’s syndrome, HIV infection and nuchal fibroma
Clinical features
  • Symmetrical non pitting edema and dermal hardening, which affects the posterior and lateral aspect of the neck, face, upper trunk and upper limbs
  • Rarely affects lower abdomen and legs
Case reports
Microscopic (histologic) description
  • Epidermis appear slightly thinned or normal
  • Thickened reticular dermis, often at expense of subcutaneous fat; eccrine glands in upper third of mid dermis
  • Collagen fibers are broadened, abnormally separated by clear spaces, which may contain mucin
  • May be mild chronic inflammatory cell infiltrate in superficial dermis, increased mast cells, but normal amount of fibroblasts
Negative stains
  • Negative direct immunofluorescence
Differential diagnosis
  • Scleroderma: appendages are atrophic or absent; diffuse dermal sclerosis, not the fenestrated appearance of scleredema
Additional references