Skin-nontumor / Clinical dermatology
Other dermatoses
Scleroderma

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 21 July 2016, last major update August 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Scleroderma [title] skin
Definition / General
  • Either localized (morphea) or systemic (involving skin of face, upper trunk, hands and arms, esophagus, heart and lungs)
  • May have visceral disease without skin disease
  • May be associated with Raynaud's phenomenon, Borrelia burgdorferi infection
Clinical Features
  • Usually presents on trunk or extremities as one or several indurated plaques with ivory center and violaceous border (the "lilac ring")
  • Also lesions confined to breast
  • May have irregular areas of hyperpigmentation or hypopigmentation
  • Occasionally more than one type is present
Clinical Images

Images hosted on PathOut servers:

Breast skin, morphea, courtesy of Mark R. Wick, M.D.

Courtesy of Michael Inskip, M.D.



Image hosted on other servers:

Dermal sclerosis

Micro Description
  • Thickening and hyalinization of connective tissue of deep dermis, subcutaneous fat and muscular fascia, with perivascular and focal interstitial lymphocytic and plasma cell infiltrate in subcutaneous fat
  • Frequent atrophy of adnexal structures, increased fibroblasts, thickening and luminal narrowing of small vessels, blunting of dermal-subcutis interface, diminished elastic tissue
  • Often atrophy of epidermis, mucin deposition
  • Variable dystrophic calcification of blood vessels
  • Control biopsy from adjacent normal skin is helpful
Micro Images

Images hosted on PathOut servers:

Breast skin, morphea, courtesy of Mark R. Wick, M.D.

Missing Image

Morphea, courtesy of Joel Pinczewski, M.D., Ph.D.

Negative Stains
  • Immunoglobulins
Differential Diagnosis
Additional References