Skin inflammatory (nontumor)
Infectious disorders
Smallpox vaccination


Topic Completed: 1 September 2010

Revised: 1 April 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Smallpox vaccination [title]
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Cite this page: Hamodat M Smallpox vaccination. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorsmallpoxvaccination.html. Accessed June 15th, 2019.
Definition / general
  • Diffuse, pruritic, erythematous macules and papules that usually occur 7 - 11 days (range, 2 days to 7 weeks) after routine smallpox vaccination
Clinical features
  • Serious but uncommon complications of smallpox vaccination include eczema vaccinatum, vaccinia necrosum, generalized vaccinia and encephalitis (Centers for Disease Control)
  • Less serious but more common complications include keloid, contact dermatitis, erythema multiforme, pityriasis rosea, granuloma annulare and vesicular spongiotic dermatitis with eosinophils (Arch Dermatol 2010;146:656)
Treatment
  • Symptomatic
Clinical images

Images hosted on other servers:

Normal "robust" reaction

Hyperemic and indurated band extending from vaccination site

Vaccinia necrosum

Microscopic (histologic) description
  • Smallpox vaccination: possible features include eczema vaccinatum, vaccinia necrosum, generalized vaccinia, keloid, contact dermatitis, erythema multiforme, pityriasis rosea, granuloma annulare and vesicular spongiotic dermatitis with eosinophils
  • Smallpox infection (historical features-smallpox has now been eradicated): variable degree of hyperkeratosis and acanthosis, ballooning degeneration of keratinocytes, cytoplasmic eosinophilic inclusion bodies and dermal chronic inflammatory cell infiltrate
Microscopic (histologic) images

Images hosted on other servers:

Various images

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