Skin inflammatory (nontumor)
Spongiotic, psoriasiform and pustular reaction patterns
Spongiotic dermatitis

Topic Completed: 1 August 2011

Revised: 26 March 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Spongiotic dermatitis

Mowafak Hamodat, M.B.Ch.B., M.Sc.
Page views in 2018: 9,030
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Cite this page: Hamodat M Spongiotic dermatitis. website. Accessed December 11th, 2019.
Definition / general
  • Clinically correlates with eczematous dermatitis
  • Encompasses a large number of diseases, including allergic contact dermatitis and irritant contact dermatitis
Microscopic (histologic) description
  • Intraepidermal edema with clear spaces separating keratinocytes
  • Acute: also perivascular lymphocytic infiltrates in upper dermis, lymphocyte exocytosis
  • Subacute: focal parakeratosis, acanthosis, papillomatosis, eosinophils
  • Chronic: prominent parakeratosis, acanthosis, papillomatosis; may have minimal spongiosis; fibroplasia of papillary and upper reticular dermis; variable inflammatory infiltrate
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.


Contributed by Dr. Asmaa Gaber

Spongiotic dermatitis

Differential diagnosis
  • Early cutaneous T cell lymphoma: large numbers of cerebriform nuclei, Pautrier’s microabscesses, epidermotropism
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