Reviewer: Mowafak Hamodat MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns (Canada) (see Reviewers page)
Revised: 9 July 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Severe adverse cutaneous drug reaction that predominantly involves the skin and mucous membranes (Orphanet J Rare Dis 2010 Dec 16;5:39)
● Systemic form of erythema multiforme with fever
● Toxic epidermal necrolysis: variant with full thickness epidermal necrosis, but with intact cornified layer, subepidermal bullae and sloughing of skin/mucosal epithelium; analogous to severe burn
● Common in children
● Often involves lips, oral mucosa or other mucosa with erosions and hemorrhagic crusts
● Infection of affected areas may cause life threatening sepsis
● Full thickness epidermal necrosis with separation of epidermis from dermis
● Necrotic keratinocytes at edge of bullae
● Staphylococcal scalded skin syndrome: similar clinically, but plane of cleavage is in granular layer
● Necrolytic migratory erythema: also called glucagonoma syndrome – has superficial epidermal necrosis
End of Skin-nontumor > Blistering disorders > Stevens-Johnson syndrome
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