Skin inflammatory (nontumor)
Vesiculobullous and acantholytic reaction patterns
Subcorneal pustular dermatosis


Topic Completed: 1 July 2011

Revised: 28 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Subcorneal pustular dermatosis [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M Subcorneal pustular dermatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorsubcornealpustulardermatosis.html. Accessed November 14th, 2019.
Definition / general
  • Rare, recurrent, noninfective, nonautoimmune pustular eruption of unknown etiology
Terminology
  • Also called Sneddon-Wilkinson disease
Epidemiology
  • Associated with benign or malignant IgA paraproteinemia, rheumatoid arthritis, SLE, bullous pemphigoid, squamous cell carcinoma of the bronchus and metastatic gatrinomas
Clinical features
  • Large pustules on trunk and body folds
Treatment
Clinical images

Images hosted on other servers:

Symmetric and diffusely scattered vesicopustules on trunk and extremities

Microscopic (histologic) description
  • Large unilocular subcorneal pustule containing a small amount of neutrophils and minimal acantholysis
  • May be psoriasiform
  • Superficial dermis has neutrophils and lymphocytes
Microscopic (histologic) images

Images hosted on other servers:

Subcorneal pustule containing a few neutrophils and acantholytic cells

Differential diagnosis
  • Impetigo
  • Pustular psoriasis
  • Staphylococcal scalded skin syndrome (SSSS)
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