Skin inflammatory (nontumor)
Vesiculobullous and acantholytic reaction patterns
Subcorneal pustular dermatosis

Author: Mowafak Hamodat, M.D., M.Sc. (see Authors page)

Revised: 17 October 2018, last major update July 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Subcorneal pustular dermatosis [title]

Page views in 2018: 4,093
Page views in 2019 to date: 284
Cite this page: Hamodat, M. Subcorneal pustular dermatosis. website. Accessed January 21st, 2019.
Definition / general
  • Rare, recurrent, noninfective, nonautoimmune pustular eruption of unknown etiology
  • Also called Sneddon-Wilkinson disease
  • Associated with benign or malignant IgA paraproteinemia, rheumatoid arthritis, SLE, bullous pemphigoid, squamous cell carcinoma of the bronchus and metastatic gatrinomas
Clinical features
  • Large pustules on trunk and body folds
Clinical images

Images hosted on other servers:

Symmetric and diffusely scattered vesicopustules on trunk and extremities

Microscopic (histologic) description
  • Large unilocular subcorneal pustule containing a small amount of neutrophils and minimal acantholysis
  • May be psoriasiform
  • Superficial dermis has neutrophils and lymphocytes
Microscopic (histologic) images

Images hosted on other servers:

Subcorneal pustule containing a few neutrophils and acantholytic cells

Differential diagnosis
  • Impetigo
  • Pustular psoriasis
  • Staphylococcal scalded skin syndrome (SSSS)