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Skin-nontumor
Blistering disorders
Subcorneal pustular dermatosis
Reviewer: Mowafak Hamodat MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns (Canada) (see Reviewers
page)
Revised: 9 July 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
Definition
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● Rare, recurrent, non-infective, non-autoimmune pustular eruption of unknown etiology
Terminology
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● Also called Sneddon-Wilkinson disease
Epidemiology
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● Associated with benign or malignant IgA paraproteinemia, rheumatoid arthritis, SLE, bullous pemphigoid, squamous cell carcinoma of the bronchus and metastatic gatrinomas
Treatment
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● Dapsone as first-like treatment; acitretin for non-responders to dapspone (J Dermatolog Treat 2010;21:114)
Clinical description
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● Large pustules on trunk and body folds
Clinical images
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Symmetric and diffusely scattered vesicopustules on trunk and extremities
Micro description
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● Large unilocular subcorneal pustule containing a small amount of neutrophils and minimal acantholysis
● May be psoriasiform
● Superficial dermis has neutrophils and lymphocytes
Micro images
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Subcorneal pustule containing a few neutrophils and acantholytic cells
Differential diagnosis
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● Impetigo
● Staphylococcal scalded skin syndrome (SSSS)
● Pustular psoriasis
Additional references
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End of Skin-nontumor > Blistering disorders > Subcorneal pustular dermatosis
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