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Skin-nontumor / Clinical Dermatology

Infectious disorders

Syphilis


Reviewer: Mowafak Hamodat MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns (Canada) (see Reviewers page)
Revised: 22 March 2011, last major update March 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Clinical features
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● Secondary lesions occur on face and trunk; are maculopapular and resemble drug eruption, lichen planus and psoriasis
● May present as moth-eaten alopecia on scalp, mucous patches on tongue
● Diagnose by serology

Clinical description
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● Scaly, flesh-colored to erythematous papules or annular plaques
● Copper macules on palms and soles

Micro description
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● Dense perivascular or diffuse plasma cell infiltrate with marked endothelial swelling and proliferation in blood vessels
● May have noncaseating granulomas, vacuolar interface change, acanthosis, spongiosis or lymphocyte exocytosis

Micro images
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Primary syphilis


Various images

Positive stains
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● Steiner stain (71% sensitive)

End of Skin-nontumor / Clinical Dermatology > Infectious disorders > Syphilis


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