Table of Contents
Clinical features | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stainsCite this page: Hamodat M Syphilis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorsyphilis.html. Accessed December 11th, 2019.
Clinical features
- Secondary lesions occur on face and trunk; are maculopapular and resemble drug eruption, lichen planus and psoriasis
- May present as moth-eaten alopecia on scalp, mucous patches on tongue
- Diagnose by serology
- Scaly, flesh-colored to erythematous papules or annular plaques
- Copper macules on palms and soles
Microscopic (histologic) description
- Dense perivascular or diffuse plasma cell infiltrate with marked endothelial swelling and proliferation in blood vessels
- May have noncaseating granulomas, vacuolar interface change, acanthosis, spongiosis or lymphocyte exocytosis
Microscopic (histologic) images
Positive stains
- Steiner stain (71% sensitive)
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