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Skin inflammatory (nontumor)
Infectious disorders
Syphilis
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Syphilis skin [title]
Infectious disorders
Syphilis
Topic Completed: 1 March 2011
Revised: 23 July 2019
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Syphilis skin [title]
Table of Contents
Clinical features | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stainsCite this page: Hamodat M Syphilis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorsyphilis.html. Accessed August 24th, 2019.
Clinical features
- Secondary lesions occur on face and trunk; are maculopapular and resemble drug eruption, lichen planus and psoriasis
- May present as moth-eaten alopecia on scalp, mucous patches on tongue
- Diagnose by serology
- Scaly, flesh-colored to erythematous papules or annular plaques
- Copper macules on palms and soles
Clinical images
Contributed by Dr. Mark R. Wick
Secondary
Gumma
Microscopic (histologic) description
- Dense perivascular or diffuse plasma cell infiltrate with marked endothelial swelling and proliferation in blood vessels
- May have noncaseating granulomas, vacuolar interface change, acanthosis, spongiosis or lymphocyte exocytosis
Microscopic (histologic) images
Contributed by
Hillary Rose Elwood, M.D.
Dense plasma cell infiltrate
Spirochete immunostain
Contributed by
Dr. Mark R. Wick
Steiner stain, secondary
Images hosted on other servers:
Primary syphilis
Positive stains
- Steiner stain (71% sensitive)
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