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Table of Contents
Clinical features | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stainsCite this page: Hamodat, M. Syphilis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorsyphilis.html. Accessed March 22nd, 2019.
Clinical features
- Secondary lesions occur on face and trunk; are maculopapular and resemble drug eruption, lichen planus and psoriasis
- May present as moth-eaten alopecia on scalp, mucous patches on tongue
- Diagnose by serology
- Scaly, flesh-colored to erythematous papules or annular plaques
- Copper macules on palms and soles
Clinical images
Images hosted on PathOut servers:
Contributed by Dr. Mark R. Wick
Secondary
Gumma
Microscopic (histologic) description
- Dense perivascular or diffuse plasma cell infiltrate with marked endothelial swelling and proliferation in blood vessels
- May have noncaseating granulomas, vacuolar interface change, acanthosis, spongiosis or lymphocyte exocytosis
Microscopic (histologic) images
Images hosted on PathOut servers:
Contributed by
Hillary Rose Elwood, M.D.
Dense plasma cell infiltrate
Spirochete immunostain
Contributed by
Dr. Mark R. Wick
Steiner stain, secondary
Images hosted on other servers:
Primary syphilis
Positive stains
- Steiner stain (71% sensitive)
