Skin inflammatory (nontumor)
Infectious disorders
Syphilis


Topic Completed: 1 March 2011

Revised: 23 July 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Syphilis skin [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M Syphilis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorsyphilis.html. Accessed August 24th, 2019.
Clinical features
  • Secondary lesions occur on face and trunk; are maculopapular and resemble drug eruption, lichen planus and psoriasis
  • May present as moth-eaten alopecia on scalp, mucous patches on tongue
  • Diagnose by serology
  • Scaly, flesh-colored to erythematous papules or annular plaques
  • Copper macules on palms and soles
Clinical images

Contributed by Dr. Mark R. Wick

Secondary

Gumma

Microscopic (histologic) description
  • Dense perivascular or diffuse plasma cell infiltrate with marked endothelial swelling and proliferation in blood vessels
  • May have noncaseating granulomas, vacuolar interface change, acanthosis, spongiosis or lymphocyte exocytosis
Microscopic (histologic) images

Contributed by
Hillary Rose Elwood, M.D.

Dense plasma cell infiltrate

Spirochete immunostain


 Contributed by
 Dr. Mark R. Wick

Steiner stain, secondary



Images hosted on other servers:

Primary syphilis

Positive stains
  • Steiner stain (71% sensitive)
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