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Skin-Melanocytic Tumors
Halo nevus
Last major update: November 2008 - next update November 2009
Revised: 28 June 2009
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Nevus surrounded by zone of hypopigmented skin
Terminology
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● Also called leukoderma acquisitum centrifugum, Sutton’s nevus (Am J Dermatopathol 2003;25:349)
Clinical
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● Usually due to regression caused by cell mediated immunity, or less commonly humoral immunity or granulomatous inflammation (Am J Dermatopathol 2008;30:233)
● In contrast to melanoma, there is no fibrosis (J Cutan Pathol 2007;34:301)
● Trunk of young patients; may be single or multiple
● Seen in 18% of Turner’s syndrome patients (J Am Acad Dermatol 2004;51:354)
● Note: classify based on nevus cell population because halo phenomenon occurs in various nevus types (J Cutan Pathol 1995;22:342)
Treatment and prognosis
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● Observation, excision (for cosmetic reasons), laser for facial lesions to induce repigmentation (J Cosmet Laser Ther 2007;9:245)
Clinical images
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Various images
Dermoscopic images
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Normal mole and halo nevus 1 year later 25 year old man
Micro description
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● Residual melanocytes with heavy infiltration by lymphocytes and histiocytes that destroy pigment containing cells
Micro images
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Early regression Various images CD8+ T cells
Contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain:
CD3 (T cells) CD20 (B cells) Melan-A
Video
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Differential Diagnoses
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● Lymphoma
● Melanoma
● Dermatitis
Additional references
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End of Skin-Melanocytic Tumors > Halo nevus
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