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Skin-Melanocytic tumors
Ephelis (freckle)
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Revised: 4 July 2009, last major update November 2008
Copyright: (c) 2005-2009, PathologyOutlines.com, Inc.
Terminology
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● Plural - ephelides
Clinical
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● Affects sun exposed areas of skin of susceptible individuals (fair skin type and red hair)
● Appears in early childhood; fades in winter and reappears in summer
● Risk factor for skin cancer
● Due to variations in melanocortin-1-receptor gene (Hum Mol Genet 2001;10:1701)
Clinical images
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Face Face and upper body
Micro description
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● Mild hyperpigmentation of basal keratinocytes, normal architecture
Additional references
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End of Skin-Melanocytic Tumors > Ephelis (freckle)
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