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Skin-Melanocytic Tumors

Lentiginous melanoma

 

Last major update: November 2008 - next update November 2009

Revised: 11 July 2009

Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.

Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.

 

Definition

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● First described in 2005 (Mod Path 2005;18:1397)

● May remain in situ for prolonged periods before invasion

● May be an analogue of lentigo maligna on non-severely sun-damaged skin (J Cutan Pathol 2007;34:296)

● May recur locally

 

Epidemiology

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● Elderly patients

 

Micro description

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● Lentiginous proliferation of melanocytes at dermoepidermal junction both as single cells and as small nests with areas of confluent growth, extending to edges of biopsy

● Prominent atypia of melanocytes and invasion may be evident only at excision

● Variable dermal fibrosis

● No solar elastosis

 

Micro images

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Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author                                                   Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Various images                                  Reexcisions demonstrate invasive disease

 

 

Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

MART1 and MITF highlight melanocytic proliferation and pagetoid spread

 

Differential diagnosis

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● Lentiginous nevus or dysplastic nevus

 

End of Skin-Melanocytic Tumors > Lentiginous melanoma

 

 

 

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