Last major update: November 2008 - next update November 2009
Revised: 11 July 2009
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
● First described in 2005 (Mod Path 2005;18:1397)
● May remain in situ for prolonged periods before invasion
● May be an analogue of lentigo maligna on non-severely sun-damaged skin (J Cutan Pathol 2007;34:296)
● May recur locally
● Elderly patients
● Lentiginous proliferation of melanocytes at dermoepidermal junction both as single cells and as small nests with areas of confluent growth, extending to edges of biopsy
● Prominent atypia of melanocytes and invasion may be evident only at excision
● Variable dermal fibrosis
● No solar elastosis
Various images Reexcisions demonstrate invasive disease
MART1 and MITF highlight melanocytic proliferation and pagetoid spread
● Lentiginous nevus or dysplastic nevus
End of Skin-Melanocytic Tumors > Lentiginous melanoma
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