Skin-melanocytic tumor
Nevi
Junctional nevus

Author: Christopher Hale, M.D. (see Authors page)

Revised: 22 February 2017, last major update February 2017

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Junctional nevus [title]
Cite this page: Junctional nevus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumormelanocyticJunctnevus.html. Accessed October 23rd, 2017.
Definition / general
  • Melanocytic proliferation restricted to basal epidermis (junctional area)
  • Earliest stage of intraepidermal melanocytic proliferation
Terminology
  • Lentigo simplex:
    • Also called lentigo, lentigines
    • Often in acral sites
    • Precursor lesion to nevi, with proliferation of melanocytes (but no nests) in epidermal basal layer along rete ridges (DermNet NZ)
  • Multiple lentigines:
    • Associated with Peutz-Jeghers syndrome, centrofacial lentiginosis, Moynahan’s syndrome, LEOPARD syndrome, Carney’s syndrome and xeroderma pigmentosum
Epidemiology
  • Traditionally considered more common in children (possible sampling bias), may actually occur in all ages (J Am Acad Dermatol 2007;56:825)
  • Melanomas may arise from junctional nevi
Sites
Clinical features
  • Small, flat or slightly elevated; non-hairy, deeply pigmented
Case reports
Treatment
Dermoscopy
  • Regular pigmented network of brown and uniform color, more prominent in center with gradual fading to borders (reticular pattern)
  • May have black or brown globules and dots regularly distributed inside lesion (usually in central region)
Microscopic (histologic) description
  • Rounded nests of melanocytes / nevus cells on epidermal side of dermoepidermal junction, originating from tips of rete ridges
  • Variable lentiginous melanocytic hyperplasia
Microscopic (histologic) images

Images hosted on other servers:
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Breast skin, courtesy of Dr. Mark R. Wick

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Junctional nests

Differential diagnosis