Skin melanocytic tumor
Blue nevi, pigmented epithelioid melanocytomas and dermal melanocytoses
Common blue nevus


Topic Completed: 1 September 2014

Revised: 13 May 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: blue nevus [title] common type

Christopher S. Hale, M.D.
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Cite this page: Hale C. Common blue nevus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumormelanocyticbluenevus.html. Accessed September 23rd, 2019.
Definition / general
  • Collection of benign type C melanocytes (Schwann cell-like morphology) in dermis (eMedicine)
  • Blue color due to Tyndall effect of selective absorption of parts of the light spectrum by deeply located (dermal) melanin pigment, which is usually abundant
  • No relationship to blue rubber bleb nevus syndrome (eMedicine)
  • May be due to arrested migration of immature melanocytes in dermis
  • May evolve from ordinary non-blue nevi (Ann Diagn Pathol 2007;11:160)
  • Numerous histologic variants and related entities; see also blue nevus variants and eye-conjunctiva
Epidemiology
  • Associated with neurocutaneous melanosis
  • Young adults, particularly women
Sites
  • Usually small lesions of head, neck or upper extremity
Clinical features
  • Heavily pigmented, solitary, < 1 cm, slightly elevated or dome-shaped
Case reports
Dermoscopy
Microscopic (histologic) description
  • Ill defined deep dermal proliferation of spindled (Type C) melanocytes with abundant pigment and melanophages, dissecting dermal collagen and often extending into subcutis
  • No junctional or superficial dermal involvement
Microscopic (histologic) images

Contributed by Angel Fernandez-Flores, M.D., Ph.D.
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Contributed by Dr. Mark R. Wick
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Blue nevus (breast skin)


Contributed by John Irlam, D.O.

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Various images

Positive stains
  • S100, HMB45, MelanA / Mart1 (Arch Pathol Lab Med 2011;135:853) and other melanocytic stains; variable CD34
  • HMB45 staining is usually diffuse; maturational pattern of staining seen in other nevi often not present
Molecular / cytogenetics description
Differential diagnosis
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