Skin melanocytic tumor
Blue nevi, pigmented epithelioid melanocytomas and dermal melanocytoses
Atypical cellular blue nevus

Topic Completed: 1 September 2014

Revised: 15 October 2019

Copyright: 2003-2017,, Inc.

PubMed Search: atypical cellular blue nevus

Christopher S. Hale, M.D.
Page views in 2018: 750
Page views in 2019 to date: 923
Cite this page: Hale CS. Atypical cellular blue nevus. website. Accessed October 19th, 2019.
Definition / general
  • All ages, especially children and young adults
  • Buttocks > head and neck > extremities
Clinical features
  • Bluish, deep, dermal nodules
Case reports
  • Treat conservatively with excision
Microscopic (histologic) description
  • Similar to cellular blue nevi with dumbbell-shaped cellular nests extending into dermis, often within a conventional blue nevus
  • Myxoid degeneration, hemorrhage and stromal hyalinization can occur, but do not mistake for tumor necrosis (Arch Pathol Lab Med 2011;135:327)
  • Cystic degeneration may occur in nevi at pressure points (buttocks); must distinguish from tumor necrosis (Histopathology 2004;45:433)
  • Infiltrative margin or asymmetry, cellular atypia, prominent nucleoli and mitotic rate of less than 2 per square millimeter
Positive stains
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