Skin melanocytic tumor
Blue nevi, pigmented epithelioid melanocytomas and dermal melanocytoses
Epithelioid blue nevus


Topic Completed: 1 September 2014

Minor changes: 2 April 2020

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PubMed Search: epithelioid blue nevus

Christopher S. Hale, M.D.
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Cite this page: Hale CS. Epithelioid blue nevus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumormelanocyticbluenevusepithelioid.html. Accessed May 24th, 2020.
Definition / general
  • Very rare
  • Heavily pigmented variant of blue nevus, notable for polygonal melanocytes
Terminology
  • Some authors use “pigmented epithelioid melanocytoma” (PEM) to describe epithelioid blue nevi that is not associated with Carney complex (Arch Pathol Lab Med 2011;135:327)
Epidemiology
Sites
  • Often trunk / extremities
Case reports
Microscopic (histologic) description
  • Poorly circumscribed, but heavily symmetric pigmented dermal lesion
  • Short fascicles, small nests and single cells
  • Two populations of melanocytes: (a) intensely pigmented, globular and fusiform and (b) lightly pigmented, polygonal with large cytoplasm (J Cutan Pathol 2000;27:218)
  • No / rare mitotic figures
  • Usually no maturation and no dermal fibrosis
Molecular / cytogenetics description
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