Skin melanocytic tumor
Spitzoid neoplasms, BAP1 inactivated neoplasms, and deep penetrating nevi
Deep penetrating nevus


Topic Completed: 1 June 2014

Revised: 15 May 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: deep penetrating nevus [title]

Christopher S. Hale, M.D.
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Cite this page: Hale C. Deep penetrating nevus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumormelanocyticdeeppennevus.html. Accessed July 19th, 2019.
Definition / general
  • Very cellular melanocytic nevus consisting of spindled melanocytes extending into reticular dermis or subcutis (Arch Dermatol 1993;129:328)
Terminology
Epidemiology
Sites
Clinical features
Case reports
Treatment
Clinical images

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Linear distribution of nevi behind ear

Microscopic (histologic) description
  • Nevus whose dermal component extends into reticular dermis or subcutis
  • Cellular, nested or fascicular with abundant pigment and mild atypia
  • Usually inconspicuous junctional component
  • Plump regular nests of melanocytes in dermis
  • Mild cytologic atypia with some nuclear pleomorphism, small to medium-sized eosinophilic nucleolus (Arch Pathol Lab Med 2011;135:321)
  • Occasional normal dermal mitotic figures, patchy mononuclear inflammatory cell infiltrate
  • Absence of maturation
  • May be combined with other nevi
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick
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Breast skin



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Various images

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H&E

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Various images

Differential diagnosis
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