Skin - Melanocytic tumor
Desmoplastic Spitz nevus

Author: Christopher Hale, M.D. (see Authors page)

Revised: 24 February 2017, last major update March 2013

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Desmoplastic Spitz nevus

See also Spitz nevus
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Cite this page: Desmoplastic Spitz nevus. website. Accessed January 23rd, 2019.
Definition / general
  • Spitz (spindle and epithelioid cell) nevus with dense eosinophilic stroma
  • Other Spitz nevus features present (Kamino bodies, etc.)
  • Uncertain relationship to "desmoplastic (sclerotic) nevus" (Am J Dermatopathol 2011;33:35)
  • Mostly young women
Clinical features
  • Solitary papules on limbs of young adults (not a common site for melanoma)
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on PathOut server:

Symmetrical lesion shows maturation of lesional cells in the dermis with attenuated single cells
among reticular dermis collagen bundles at the base but unlike desmoplastic melanoma, the
intraepidermal component does not extend substantially beyond the dermal component and
there are no clusters of mitotically active epithelioid melanocytes in the superficial dermis (AFIP)

Images hosted on other servers:

Melanocytes with spitzoid appearance

Near-dermal lesion

Various images

Various images

Positive stains
Differential diagnosis