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Skin-melanocytic tumor
Nevi
Lentiginous nevus

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 21 November 2014, last major update November 2012
Copyright: (c) 2002-2014, PathologyOutlines.com, Inc.

General
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Terminology
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Epidemiology
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Clinical features
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Case reports
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Treatment
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Clinical images
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Adjacent type with a raised hypertrichotic
portion with macular hyperpigmentation
and superimposed darker macules

A: speckled lentiginous nevus-likeappearance on abdomen;
B: darkening nevus;
C: congenital melanocytic appearance

Adjacent type with a thick hypertrichotic
inferolateral portion next to speckled
lentiginous nevus-like inguinal crease

Admixed type hypertrichotic hybrid nevus

A large unilateral speckled lentiginous nevus
that contains numerous small dark macules

Extensive speckled lentiginous nevus
Micro description
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Micro images
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A, B: melanocytes are disposed in small
nests and single cells;
C: epithelioid melanocytes with enlarged
nuclei and prominent nucleoli

A: preservation of the retiform epidermis with virtual confluent
proliferation of melanocytes at dermoepidermal junction
B: Clark level II invasion into the papillary dermis

A, B: melanocytic proliferation and pagetoid
spread of melanocytes with Mart-1 stain
C: Mitf

Nests of small and monomorphic melanocytes
at the dermoepidermal junction and within
the reticular dermis, with many melanocytes concentrated
around blood vessels and adnexal structures

Elongated rete ridges and lentiginous
proliferation of melanocytes at the
dermal-epidermal junction

Prominent basal layer pigmentation
similar to that seen in lentigo simplex
Differential diagnosis
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End of Skin-melanocytic tumor > Nevi > Lentiginous nevus


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