Skin - Melanocytic tumor
Lentiginous melanoma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 21 February 2017, last major update May 2013

Copyright: c) 2002-2017,, Inc.

PubMed Search: Lentiginous melanoma

Cite this page: Lentiginous melanoma. website. Accessed October 16th, 2018.
Definition / general
  • Rare subset of slowly progressing, radial growth phase melanoma with lentiginous proliferation of moderately atypical epithelioid melanocytes, focal pagetoid spread and nesting; not associated with architectural changes at dermoepidermal junction (Arch Pathol Lab Med 2011;135:337)
  • First described in 2005 (Mod Pathol 2005;18:1397)
  • May remain in situ for prolonged periods before invasion
  • May be an analogue of lentigo maligna on mild / moderately sun damaged skin (J Cutan Pathol 2007;34:296)
  • May recur locally
  • Distinct from acral lentiginous melanoma, lentigo maligna and superficial spreading melanoma
Microscopic (histologic) description
  • Broad lentiginous proliferation of melanocytes at dermoepidermal junction, both as single cells and as small nests with areas of confluent growth, extending to edges of biopsy
  • Prominent atypia of melanocytes and invasion may be evident only at excision
  • Preservation of retiform epidermis
  • Similar to other histologic subtypes with a lentiginous junctional proliferation (lentigo maligna, acral lentiginous and mucosal lentiginous)
  • Variable dermal fibrosis
  • No solar elastosis
Microscopic (histologic) images

Images hosted on other servers:

Various images

proliferation and
pagetoid spread
(MART1 and MITF)

Virtual confluent proliferation of melanocytes

Corresponding to Clark level II invasive melanoma