Skin - Melanocytic tumor
Melanoma
Nevoid melanoma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 21 February 2017, last major update May 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Nevoid melanoma

Cite this page: Nevoid melanoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumormelanocyticnevoidmelanoma.html. Accessed May 25th, 2017.
Definition / general
Terminology
  • Synonym: "verrucous pseudonevoid melanoma"
  • Distinct from controversial term "minimal deviation melanoma"
Epidemiology
Clinical features
  • Rare variant characterized by morphologic features of nevus
  • Behavior similar to other melanomas; may recur or metastasize causing death (Am J Dermatopathol 2001;23:167)
  • Key to diagnosis is high index of suspicion
  • Dome shaped papule, nodule or verrucous lesion
  • Tan nodule 1 cm or larger on trunk or proximal limbs of young adult
Case reports
Microscopic (histologic) description
  • Resembles ordinary compound or dermal nevus at low power, with symmetrical dome shaped or verrucous and papillomatous features, sharp lateral demarcation, inconspicuous junctional component and no pagetoid growth
  • High power shows relatively bland and monomorphic cells resembling classic nevus or epithelioid cells in Spitz nevus
  • Focal sheetlike growth pattern, nucleoli in tumor cells at base of lesion
  • Multiple dermal mitoses with atypical mitoses
  • Subtle pleomorphism and impaired maturation with depth
Microscopic (histologic) images

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Various images

Figures 3 - 6

Verrucous variant

Monotonous melanocytes

Mitotic figures


Smooth contoured variant

Expansile nodules

Pseudomaturation

Fully transformed malignant melanocytes



Lesion #1:

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Lesion #2:

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Lesion #3:

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Atypical single cells

Mitotic figures

Virtual slides

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Nevoid melanoma

Positive stains
Differential diagnosis